Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Identifieur interne : 001299 ( Main/Exploration ); précédent : 001298; suivant : 001300Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Auteurs : Bennett B. Chin [États-Unis] ; Anita Hjelemand ; Jeremy Rich ; Haijing Song ; Christopher Lascola ; Robert Storms ; Roger Mclendon ; Robert Reiman ; Kim L. Greer ; Scott D. Metzler ; Darryl Mcdougald ; Diana Dai ; Ganesan VaidyanathanSource :
- Current radiopharmaceuticals [ 1874-4729 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine (analogues et dérivés), Chloroquine (pharmacocinétique), Dose de radiation, Femelle, Glioblastome (enzymologie), Glioblastome (imagerie diagnostique), Isoenzymes (métabolisme), Leucémie L1210 (enzymologie), Lignée cellulaire tumorale, Mâle, Radio-isotopes de l'iode (pharmacocinétique), Radiopharmaceutiques (pharmacocinétique), Radiopharmaceutiques (synthèse chimique), Retinal dehydrogenase (métabolisme), Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Technique de Western, Tomographie par émission monophotonique (), Tumeurs (enzymologie), Tumeurs (imagerie diagnostique), Tumeurs du cerveau (enzymologie), Tumeurs du cerveau (imagerie diagnostique).
- MESH :
- analogues et dérivés : Chloroquine.
- enzymologie : Glioblastome, Leucémie L1210, Tumeurs, Tumeurs du cerveau.
- imagerie diagnostique : Glioblastome, Tumeurs, Tumeurs du cerveau.
- métabolisme : Isoenzymes, Retinal dehydrogenase.
- pharmacocinétique : Chloroquine, Radio-isotopes de l'iode, Radiopharmaceutiques.
- synthèse chimique : Radiopharmaceutiques.
- Animaux, Dose de radiation, Femelle, Lignée cellulaire tumorale, Mâle, Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Technique de Western, Tomographie par émission monophotonique.
English descriptors
- KwdEn :
- Aldehyde Dehydrogenase 1, Animals, Blotting, Western, Brain Neoplasms (diagnostic imaging), Brain Neoplasms (enzymology), Cell Line, Tumor, Chloroquine (analogs & derivatives), Chloroquine (pharmacokinetics), Drug Resistance, Neoplasm, Female, Glioblastoma (diagnostic imaging), Glioblastoma (enzymology), Iodine Radioisotopes (pharmacokinetics), Isoenzymes (metabolism), Leukemia L1210 (enzymology), Male, Mice, Mice, Nude, Neoplasms (diagnostic imaging), Neoplasms (enzymology), Radiation Dosage, Radiopharmaceuticals (chemical synthesis), Radiopharmaceuticals (pharmacokinetics), Retinal Dehydrogenase (metabolism), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , analogs & derivatives : Chloroquine.
- chemical , chemical synthesis : Radiopharmaceuticals.
- chemical , metabolism : Isoenzymes, Retinal Dehydrogenase.
- chemical , pharmacokinetics : Chloroquine, Iodine Radioisotopes, Radiopharmaceuticals.
- chemical : Aldehyde Dehydrogenase 1.
- diagnostic imaging : Brain Neoplasms, Glioblastoma, Neoplasms.
- enzymology : Brain Neoplasms, Glioblastoma, Leukemia L1210, Neoplasms.
- methods : Tomography, Emission-Computed, Single-Photon.
- Animals, Blotting, Western, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Male, Mice, Mice, Nude, Radiation Dosage.
Abstract
Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroquine analogue, n.c.a. iodoquine, and the in vitro and in vivo uptake in cells with high ALDH1 content.
DOI: 10.2174/1874471011205010047
PubMed: 21864242
Affiliations:
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Chin</name><affiliation wicri:level="2"><nlm:affiliation>Duke University Medical Center, DUMC, Durham, NC 27710, USA. chin0004@mc.duke.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University Medical Center, DUMC, Durham, NC 27710</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hjelemand, Anita" sort="Hjelemand, Anita" uniqKey="Hjelemand A" first="Anita" last="Hjelemand">Anita Hjelemand</name></author><author><name sortKey="Rich, Jeremy" sort="Rich, Jeremy" uniqKey="Rich J" first="Jeremy" last="Rich">Jeremy Rich</name></author><author><name sortKey="Song, Haijing" sort="Song, Haijing" uniqKey="Song H" first="Haijing" last="Song">Haijing Song</name></author><author><name sortKey="Lascola, Christopher" sort="Lascola, Christopher" uniqKey="Lascola C" first="Christopher" last="Lascola">Christopher Lascola</name></author><author><name sortKey="Storms, Robert" sort="Storms, Robert" uniqKey="Storms R" first="Robert" last="Storms">Robert Storms</name></author><author><name sortKey="Mclendon, Roger" sort="Mclendon, Roger" uniqKey="Mclendon R" first="Roger" last="Mclendon">Roger Mclendon</name></author><author><name sortKey="Reiman, Robert" sort="Reiman, Robert" uniqKey="Reiman R" first="Robert" last="Reiman">Robert Reiman</name></author><author><name sortKey="Greer, Kim L" sort="Greer, Kim L" uniqKey="Greer K" first="Kim L" last="Greer">Kim L. Greer</name></author><author><name sortKey="Metzler, Scott D" sort="Metzler, Scott D" uniqKey="Metzler S" first="Scott D" last="Metzler">Scott D. Metzler</name></author><author><name sortKey="Mcdougald, Darryl" sort="Mcdougald, Darryl" uniqKey="Mcdougald D" first="Darryl" last="Mcdougald">Darryl Mcdougald</name></author><author><name sortKey="Dai, Diana" sort="Dai, Diana" uniqKey="Dai D" first="Diana" last="Dai">Diana Dai</name></author><author><name sortKey="Vaidyanathan, Ganesan" sort="Vaidyanathan, Ganesan" uniqKey="Vaidyanathan G" first="Ganesan" last="Vaidyanathan">Ganesan Vaidyanathan</name></author></analytic><series><title level="j">Current radiopharmaceuticals</title><idno type="eISSN">1874-4729</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde Dehydrogenase 1</term><term>Animals</term><term>Blotting, Western</term><term>Brain Neoplasms (diagnostic imaging)</term><term>Brain Neoplasms (enzymology)</term><term>Cell Line, Tumor</term><term>Chloroquine (analogs & derivatives)</term><term>Chloroquine (pharmacokinetics)</term><term>Drug Resistance, Neoplasm</term><term>Female</term><term>Glioblastoma (diagnostic imaging)</term><term>Glioblastoma (enzymology)</term><term>Iodine Radioisotopes (pharmacokinetics)</term><term>Isoenzymes (metabolism)</term><term>Leukemia L1210 (enzymology)</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Neoplasms (diagnostic imaging)</term><term>Neoplasms (enzymology)</term><term>Radiation Dosage</term><term>Radiopharmaceuticals (chemical synthesis)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Retinal Dehydrogenase (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chloroquine (analogues et dérivés)</term><term>Chloroquine (pharmacocinétique)</term><term>Dose de radiation</term><term>Femelle</term><term>Glioblastome (enzymologie)</term><term>Glioblastome (imagerie diagnostique)</term><term>Isoenzymes (métabolisme)</term><term>Leucémie L1210 (enzymologie)</term><term>Lignée cellulaire tumorale</term><term>Mâle</term><term>Radio-isotopes de l'iode (pharmacocinétique)</term><term>Radiopharmaceutiques (pharmacocinétique)</term><term>Radiopharmaceutiques (synthèse chimique)</term><term>Retinal dehydrogenase (métabolisme)</term><term>Résistance aux médicaments antinéoplasiques</term><term>Souris</term><term>Souris nude</term><term>Technique de Western</term><term>Tomographie par émission monophotonique ()</term><term>Tumeurs (enzymologie)</term><term>Tumeurs (imagerie diagnostique)</term><term>Tumeurs du cerveau (enzymologie)</term><term>Tumeurs du cerveau (imagerie diagnostique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Isoenzymes</term><term>Retinal Dehydrogenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Chloroquine</term><term>Iodine Radioisotopes</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aldehyde Dehydrogenase 1</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Glioblastome</term><term>Leucémie L1210</term><term>Tumeurs</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term><term>Leukemia L1210</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Glioblastome</term><term>Tumeurs</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Isoenzymes</term><term>Retinal dehydrogenase</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Chloroquine</term><term>Radio-isotopes de l'iode</term><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Cell Line, Tumor</term><term>Drug Resistance, Neoplasm</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Radiation Dosage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dose de radiation</term><term>Femelle</term><term>Lignée cellulaire tumorale</term><term>Mâle</term><term>Résistance aux médicaments antinéoplasiques</term><term>Souris</term><term>Souris nude</term><term>Technique de Western</term><term>Tomographie par émission monophotonique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroquine analogue, n.c.a. iodoquine, and the in vitro and in vivo uptake in cells with high ALDH1 content.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Dai, Diana" sort="Dai, Diana" uniqKey="Dai D" first="Diana" last="Dai">Diana Dai</name><name sortKey="Greer, Kim L" sort="Greer, Kim L" uniqKey="Greer K" first="Kim L" last="Greer">Kim L. Greer</name><name sortKey="Hjelemand, Anita" sort="Hjelemand, Anita" uniqKey="Hjelemand A" first="Anita" last="Hjelemand">Anita Hjelemand</name><name sortKey="Lascola, Christopher" sort="Lascola, Christopher" uniqKey="Lascola C" first="Christopher" last="Lascola">Christopher Lascola</name><name sortKey="Mcdougald, Darryl" sort="Mcdougald, Darryl" uniqKey="Mcdougald D" first="Darryl" last="Mcdougald">Darryl Mcdougald</name><name sortKey="Mclendon, Roger" sort="Mclendon, Roger" uniqKey="Mclendon R" first="Roger" last="Mclendon">Roger Mclendon</name><name sortKey="Metzler, Scott D" sort="Metzler, Scott D" uniqKey="Metzler S" first="Scott D" last="Metzler">Scott D. Metzler</name><name sortKey="Reiman, Robert" sort="Reiman, Robert" uniqKey="Reiman R" first="Robert" last="Reiman">Robert Reiman</name><name sortKey="Rich, Jeremy" sort="Rich, Jeremy" uniqKey="Rich J" first="Jeremy" last="Rich">Jeremy Rich</name><name sortKey="Song, Haijing" sort="Song, Haijing" uniqKey="Song H" first="Haijing" last="Song">Haijing Song</name><name sortKey="Storms, Robert" sort="Storms, Robert" uniqKey="Storms R" first="Robert" last="Storms">Robert Storms</name><name sortKey="Vaidyanathan, Ganesan" sort="Vaidyanathan, Ganesan" uniqKey="Vaidyanathan G" first="Ganesan" last="Vaidyanathan">Ganesan Vaidyanathan</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Chin, Bennett B" sort="Chin, Bennett B" uniqKey="Chin B" first="Bennett B" last="Chin">Bennett B. Chin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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